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Dangerous Drugs and Drug Abuse in the News

Today is Tuesday June 19, 2007

Do Doctors Sometimes Fail Their Heart Failure Patients?

Inotropic drugs make you feel better, but do you live longer? New study seeks answers.

Aug. 21, 2003 - What's the best way to manage a patient who's dying of heart failure? And just how do physicians make decisions about this ever-growing population of patients, particularly those in the end stages of the disease?

These are two questions that a cardiologist at Saint Louis University is seeking to answer as part of research sponsored by the National Institutes of Aging. The project, funded by a $721,000 grant from the NIA, begins this summer and will continue for four years.

"Congestive heart failure is a disease of increasing prevalence, accounting for high morbidity and mortality," said lead researcher Paul J. Hauptman, M.D., a cardiologist at Saint Louis University School of Medicine. "This is a disease of the elderly, so as baby boomers age we need to start understanding more about how physicians in multiple specialty areas actually treat these patients. Ultimately, we want to figure out how to best take care of patients with end-stage heart failure."

The risk of heart failure, which affects 2 to 3 million Americans, is more common among elderly patients and increases with age. About 5 percent of those who are 75 have the condition, compared to 1 percent of those age 50.

Dr. Hauptman's study has two major parts:

The study evaluates a medical therapy, the infusion of inotropic drugs, which is associated with high costs, unproven clinical efficacy and the potential to shorten survival while achieving palliation. "This therapy makes patients feel better, but it's unclear whether it helps them live longer," Hauptman said.

Researchers will use administrative and clinical data from several Medicare databases for the period 1997 to 2001. The population of older Medicare beneficiaries receiving and the physicians prescribing this therapy will be described and contrasted with the demographics and outcomes of older patients hospitalized for heart failure but not receiving the drugs.

The data will be used so doctors can better predict how inotrope use affects mortality and other factors in this high-risk group.

The second part involves a survey of 1,200 cardiologists, geriatricians, internists and family/general practitioners from across the country to assess how their knowledge and attitudes influence their practices in treating end-stage heart failure patients. Approximately one-third of the physicians will be known prescribers of inotropic drugs.

"We plan to investigate how physicians make decisions and the degree to which the care of the end-stage patient is influenced by physician specialty, volume or other factors," Hauptman said.

"When complete, these studies will form a framework for physicians to use when selecting care options, including palliation, for older heart failure patients near the end of life," he said.

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